molecularlifesciences:

currentsinbiology:

Inner Life of a Cell | Protein Packing (NT TImes)

Two years ago, BioVisions and Xvivo set out to upgrade their animations by capturing some of the messy complexity of protein movements. They wanted to cram a virtual cell with proteins at a more realistic density, and then have them jitter and collide

In this movie, we enter a neuron by diving through a channel on its surface. Once inside, we’re instantly surrounded by a swarm of molecules. We push through the crowd until we reach a proteasome, a barrel-shaped molecule that shreds damaged proteins so their components can be used to make new proteins.

Once more we see a vesicle being hauled by kinesin. But in this version, the kinesin doesn’t look like a molecule out for a stroll. Its movements are barely constrained randomness.

Every now and then, a tiny molecule loaded with fuel binds to one of the kinesin “feet.” It delivers a jolt of energy, causing that foot to leap off the molecular cable and flail wildly, pulling hard on the foot that’s still anchored. Eventually, the gyrating foot stumbles into contact again with the cable, locking on once more — and advancing the vesicle a tiny step forward.

This updated movie offers a better way to picture our most intricate inner workings. For one thing, it helps us to understand why we become sick. A number of diseases, such as Alzheimer’s and Parkinson’s, are caused when defective proteins clamp onto other proteins, creating toxic clumps.

Wow! New Biovisions animation does a great job of representing the crowdedness of the cell and realistic molecular dynamics. Most animations portray events as directed.

(via infinity-imagined)

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witanddelight:

High of 80 today. Minneapolis will be full of happy, pasty people.

witanddelight:

High of 80 today. Minneapolis will be full of happy, pasty people.

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girouxtiful:

pre-apocalypse:

vesticle:

AW LOOK AT HIM HE LOOKS SO PROUD OF HIMSELF LOOK AT THAT LIL SMILE OMG I CAN JUST FEEL THE HAPPINESS THIS DOG IS BEAUTIFUL OMG 

Are you fucking kidding me that’s the cutest thing I’ve ever seen

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Post work out drink #organic #greens #drinkyogreens

Post work out drink #organic #greens #drinkyogreens

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theclassyissue:

Vans Classics 2014 Spring Van Doren Sk8-Hi Reissue “Stars & Stripes”

theclassyissue:

Vans Classics 2014 Spring Van Doren Sk8-Hi Reissue “Stars & Stripes”

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Con mi green apple @gtzthania  (at Barleymash)

Con mi green apple @gtzthania (at Barleymash)

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How pretty is 10 bean soup?! #eatyocolors

How pretty is 10 bean soup?! #eatyocolors

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Monday

Monday

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